Overview
X-ray diffraction studies of protein - foldamer complexes in a multidisciplinary research program.
Program Description
Protein-protein interactions are a central issue in biological processes, and represent relevant therapeutic targets for the treatment of many diseases. The design of antagonistic molecules directed towards the disruption of these interactions requires the specific recognition of important protein surfaces. Aromatic oligomers present all the properties (high functionalization, stability and easy predictability of the structure, length flexibility) to reach that point.
The thesis will be devoted to the optimization of the design of quinoline-derived aromatic amide foldamers (see http://www.iecb.u-bordeaux.fr/teams/HUC/), using structural tools (X-ray diffraction, molecular modelling). It lies within the scope of a european multidisciplinary project associating private sector (UCB-Pharma, Belgium) and universities (Bordeaux, Wurzburg). The proteins which will be used as a basis for this study have been chosen according to their therapeutic relevance. They crystallize easily and the interaction geometry between each partner is perfectly known.
The crystallization of the aromatic oligomers tethered to the protein and their structure determination will be led in close cooperation with the private sector, which will imperatively welcome the student during the twelve months of his PhD second year. The chemical synthesis and the evaluation of the physicochemical properties of the studied molecules will be approached by the partner groups.
Research Field
Biological sciences - Other
Eligible Candidates
Biologists and/or biochemists with a background in structural biology are strongly encouraged to postulate. Additional experience in protein crystallography and X-rays diffraction would be an asset.
APPLICATIONS (including CV, research experience, and two names and contact information for references) should be sent to b.gallois@cbmn.u-bordeaux.fr. Successful candidates will be interviewed in Bordeaux early in July and will be expected to join the program in September 2010. If an interview appointment is made, certified copy of school/university certificates and other relevant material must be presented.
Application Deadline: 15/06/2010
Contact Us
Bordeaux University
Chimie Biologie des Membranes et des Nanoobjets (UMR 5218)
Academic
Bât B8, Avenue des facultés
33405 - Talence
FRANCE
email b.gallois@cbmn.u-bordeaux.fr
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
X-ray diffraction studies of protein - foldamer complexes in a multidisciplinary research program.
Program Description
Protein-protein interactions are a central issue in biological processes, and represent relevant therapeutic targets for the treatment of many diseases. The design of antagonistic molecules directed towards the disruption of these interactions requires the specific recognition of important protein surfaces. Aromatic oligomers present all the properties (high functionalization, stability and easy predictability of the structure, length flexibility) to reach that point.
The thesis will be devoted to the optimization of the design of quinoline-derived aromatic amide foldamers (see http://www.iecb.u-bordeaux.fr/teams/HUC/), using structural tools (X-ray diffraction, molecular modelling). It lies within the scope of a european multidisciplinary project associating private sector (UCB-Pharma, Belgium) and universities (Bordeaux, Wurzburg). The proteins which will be used as a basis for this study have been chosen according to their therapeutic relevance. They crystallize easily and the interaction geometry between each partner is perfectly known.
The crystallization of the aromatic oligomers tethered to the protein and their structure determination will be led in close cooperation with the private sector, which will imperatively welcome the student during the twelve months of his PhD second year. The chemical synthesis and the evaluation of the physicochemical properties of the studied molecules will be approached by the partner groups.
Research Field
Biological sciences - Other
Eligible Candidates
Biologists and/or biochemists with a background in structural biology are strongly encouraged to postulate. Additional experience in protein crystallography and X-rays diffraction would be an asset.
APPLICATIONS (including CV, research experience, and two names and contact information for references) should be sent to b.gallois@cbmn.u-bordeaux.fr. Successful candidates will be interviewed in Bordeaux early in July and will be expected to join the program in September 2010. If an interview appointment is made, certified copy of school/university certificates and other relevant material must be presented.
Application Deadline: 15/06/2010
Contact Us
Bordeaux University
Chimie Biologie des Membranes et des Nanoobjets (UMR 5218)
Academic
Bât B8, Avenue des facultés
33405 - Talence
FRANCE
email b.gallois@cbmn.u-bordeaux.fr
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
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